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KMID : 0617320030120010242
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Journal of Pharmacetical Sceiences Ewha Womans University
2003 Volume.12 No. 1 p.242 ~ p.244
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Design, Synthesis, and In Vitro Evaluation of APIO Analogue of Neplanocin A
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Moon, Hyung Ryong
Kwon, Sung Hee/Lee, Jeong Ah/Yoo, Byul Nae/Kim, Hea Ok/Chun, Moon Woo/Kim, Hee-Doo
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Abstract
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A novel apio analogue of neplanocin A was efficiently synthesized from D-ribose via stereoselective aldol-retroaldol reaction for introducing hydroxymethyl group and RCM reaction for synthesizing carbocycle, and its inhibitory activity against SAH hydrolase was assayed.
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